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Heartstrong Nutraceuticals, LLC

Heartstrong Enzyme Formula Extra Strength

Heartstrong Enzyme Formula Extra Strength

Regular price $39.95 USD
Regular price Sale price $39.95 USD
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Advanced Support for Circulation & Cardiovascular Health

HeartStrong Extra Strength combines Nattokinase + Serrapeptase, two proteolytic enzymes studied for their effects on circulation, blood flow, fibrin breakdown, cardiovascular health, and healthy inflammatory processes.

Nattokinase: Studied for Arterial Plaque, Circulation & Blood Pressure

Nattokinase is a proteolytic enzyme derived from natto, a traditional Japanese food made from fermented soybeans.

It has been studied for its fibrinolytic activity: its interaction with the body’s natural processes for breaking down fibrin, a protein involved in blood clot formation. Research has also examined Nattokinase in relation to arterial plaque, blood flow, circulation, blood pressure, and other cardiovascular markers. A scientific review describes both laboratory and human research involving nattokinase’s fibrinolytic activity and cardiovascular effects. 

What Has Human Research Found?

In one 26-week human clinical study, participants taking 6,000 FU of Nattokinase daily experienced significant changes in measurements of carotid artery health.

Researchers reported an average 36.6% reduction in measured carotid plaque size in the Nattokinase group, with plaque area decreasing from 0.25 cm² to 0.16 cm². Carotid intima-media thickness—another measurement used to evaluate artery health—also decreased significantly.  

Separate randomized, double-blind, placebo-controlled research has also reported positive findings related to blood pressure and cardiovascular markers after Nattokinase supplementation. 


Nattokinase supports your body’s natural processes for maintaining healthy circulation, normal blood flow, and cardiovascular health.

Serrapeptase: Proteolytic Enzyme & Healthy Inflammatory Response Support

Arterial plaque isn’t just fat or calcium. It is a complex material that can also contain fibrous tissue and protein-rich components that help form its structure. Serrapeptase is a proteolytic enzyme studied for its ability to act on certain protein-based materials, and its enzyme activity has been explored in relation to fibrous material and cardiovascular health.


Research has also  examined Serrapeptase in connection with inflammatory processes, swelling, mucus, tissue recovery, and proteolytic activity.

Serrapeptase’s role in HeartStrong is designed to complement Nattokinase.

Serrapeptase supports your body’s natural processes for managing protein-based material and maintaining a healthy inflammatory response.

Two Complementary Enzymes. One Extra-Strength Formula.

HeartStrong combines Serrapeptase with double-strength Nattokinase to provide concentrated daily enzyme support for:

  • Healthy circulation & normal blood flow

  • The body’s natural fibrin-clearing processes

  • Cardiovascular health

  • Healthy blood vessel function

  • A normal, healthy inflammatory response

How to Take HeartStrong Enzyme Blend

Take 2 capsules daily, according to the directions on the product label. Because these enzymes have a half life of 12 hours we recommend splitting the dose accordingly. One capsule in the morning and one capsule in the evening.

For systemic enzyme support, take HeartStrong Enzyme Blend on an empty stomach with water, separate from meals.

Consistency is key. Incorporate HeartStrong into a daily routine that makes it easy to take regularly.

Important: Nattokinase has fibrinolytic activity. If you take anticoagulant or antiplatelet medications, have a bleeding disorder, are pregnant or nursing, or have a medical or dental procedure scheduled, consult your healthcare professional before use.

Make HeartStrong Part of Your Daily Routine

Subscribe and receive your HeartStrong Nattokinase + Serrapeptase Extra Strength every 30 days, so you never have to worry about running out.

Subscribers receive free shipping directly to their door.

Complete Your HeartStrong Routine

You can combine HeartStrong Enzyme Blend with HeartStrong Vitamin D3 + K2 for a more complete cardiovascular wellness routine.

→ See How to Combine HeartStrong Enzyme Blend + Vitamin D3 & K2

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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When I started the Heartstrong protocol 10 months ago I had a Coronary Artery Calcium score of 380. Today, just ten months later, I took the test again and my results came back at 176. I had the two cardiologists at the imaging center ask me what I was doing as they had never seen a drop like this. Well, looks like I'll be on your products for life. Thanks.

380 → 176

CAC Score Drop

10 Months

Time on Protocol

54% Reduction

Overall Improvement

Ray G

Arizona