Atherosclerosis is a condition that affects millions of people worldwide. It occurs when plaque builds up inside the arteries, leading to atherosclerotic cardiovascular disease (ASCVD). This buildup makes it harder for blood to flow and can result in serious health complications such as heart attacks, strokes, and peripheral artery disease.
As concerns about heart health continue to grow, many people are seeking natural cardiovascular support. Two standout supplements—Nattokinase and Serrapeptase—are gaining recognition for their potential to support the body’s natural circulatory functions. These enzymes have been studied for their role in promoting arterial health and enhancing blood flow.
But how do they work? And can they truly help with atherosclerosis? Let’s explore the science behind these enzymes and how the Heartstrong Enzyme Supplement can become a cornerstone of your heart-healthy lifestyle.
What Is Atherosclerosis and Plaque Buildup?
Atherosclerosis happens when fatty deposits and other substances form plaques inside the blood vessel. These plaques can harden and narrow the arteries, reducing blood flow to vital organs like the heart and brain. Plaque buildup can also block blood flow completely. Additionally, plaque can lead to a blood clot that may block blood flow.
This can lead to:
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Chest pain (angina)
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Heart attack
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Stroke
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Poor circulation in the legs
Plaque buildup can also cause blood clots, which can block blood flow and lead to severe cardiovascular events. Coronary arteries can be affected by plaque buildup, leading to chest pain and heart attacks. Coronary artery disease is a critical condition affecting the arteries supplying blood to the heart. Peripheral artery disease refers to poor blood flow in the arteries of the limbs, particularly the legs.
Factors such as blood pressure, smoking, diabetes, and a sedentary lifestyle increase the risk of developing atherosclerosis.
Many people turn to diet, exercise, and supplements to support their cardiovascular health. This is where Nattokinase and Serrapeptase may help.
The Role of Enzymes in Reducing Plaque Buildup
Certain enzymes help reduce arterial plaque and support heart function. Enzymes like matrix metalloproteinases break down plaque buildup, helping prevent artery hardening. Others, such as paraoxonase, reduce inflammation—an underlying factor in many heart conditions.
This is where Nattokinase and Serrapeptase shine.
What Is Nattokinase?
The Circulation-Supporting Enzyme from Japan
Nattokinase is a potent enzyme extracted from natto, a traditional Japanese dish made from fermented soybeans. Discovered in the 1960s by Dr. Hiroyuki Sumi, it’s known for supporting the body’s ability to break down unwanted proteins in the blood.
How Nattokinase Promotes Cardiovascular Support
Research indicates that Nattokinase helps:
✔️ Promote healthy circulation
✔️ Support normal blood viscosity
✔️ Encourage the body’s natural regulation of fibrin—a key protein in clot formation
Poor circulation and thickened blood are major risk factors for atherosclerosis, making Nattokinase a valuable part of any heart health routine.
Fun fact: Unlike prescription blood thinners, Nattokinase is a natural compound with no known serious side effects when taken as directed.
What Is Serrapeptase?
The 'Miracle' Enzyme for Inflammation and Blood Clots
Serrapeptase is an enzyme originally discovered in the 1980s. It comes from bacteria found in the digestive system of silkworms. Scientists at the University of Chicago studied its effects and found that it can help support the body's natural inflammation response.
How Serrapeptase Supports Arteries
Serrapeptase is believed to:
✔️ Support the body's natural process of breaking down unwanted proteins
✔️ Help the body manage inflammation naturally
✔️ Assist the body's natural clearing of arterial deposits
Many people use Serrapeptase to support their vascular health and promote clear arteries. It is commonly used by those looking to maintain healthy circulation and normal artery function.

Can Nattokinase and Serrapeptase Help with Atherosclerosis?
Atherosclerosis is linked to plaque buildup, inflammation, and poor circulation. Since both Nattokinase and Serrapeptase support circulatory health and arterial function, they may be beneficial for those looking to support their heart naturally. Additionally, nattokinase and serrapeptase may help maintain healthy blood flow in the coronary arteries, reducing the risk of heart attacks.
Together, these enzymes may help the body:
✔️ Maintain normal blood flow
✔️ Support the natural breakdown of unwanted proteins in the blood
✔️ Promote a healthy inflammatory response
While scientific research is ongoing, many people report positive experiences with these enzymes as part of their heart health routine.
Nattokinase offers multiple health benefits, especially for circulatory and aging-related conditions. It supports healthy blood flow, helps the body maintain normal blood viscosity, and may assist in arterial health. Research suggests it also supports the body’s natural response to inflammation, thrombosis, and clot formation, benefiting those concerned about atherosclerosis, hypertension, stroke, and cognitive decline.
Food Science and Human Wellness (2024). Nattokinase as a functional food ingredient: therapeutic applications and mechanisms in age-related diseases. [Graphical abstract]. ScienceDirect. https://www.sciencedirect.com
Carotid Artery Disease and Atherosclerosis
Carotid artery disease occurs when plaque buildup restricts blood flow to the brain, increasing the risk of TIA and stroke. Symptoms may include weakness, speech difficulty, vision loss, and dizziness.
Risk factors: Blood pressure, smoking, and family history. Managing these through lifestyle changes and medications is crucial. In severe cases, procedures like carotid endarterectomy help restore blood flow and reduce stroke risk.
The Best Way to Take Nattokinase and Serrapeptase
For the best results, experts recommend taking Nattokinase and Serrapeptase on an empty stomach. This allows the enzymes to be absorbed without interference from food.
Heartstrong Enzyme Supplement is specially formulated with:
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Nattokinase, to support blood circulation and arterial health
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Serrapeptase assists the body's natural inflammatory response
This combination provides a powerful natural solution for circulatory health.
💙 Explore Heartstrong Enzyme Supplement
These statements have not been evaluated by the FDA. No information here is meant to diagnose, treat, cure, or prevent any disease. No supplements offered are meant to diagnose, treat, cure, or prevent any disease.
Supporting Arterial Health and Blood Pressure with Vitamins D3 & K2
While enzymes support circulation, proper calcium utilization is also crucial for artery health.
Many people don’t realize that excess calcium in the blood can contribute to plaque formation. This is why Vitamin K2 and Vitamin D3 are so important.
✔️ Vitamin D3 helps the body absorb calcium
✔️ Vitamin K2 directs calcium to the bones instead of the arteries
Proper calcium utilization can help prevent peripheral artery disease by supporting healthy blood flow in the arteries of the limbs.
Taking Nattokinase, Serrapeptase, Vitamin D3, and K2 together may provide well-rounded support for arterial health.
💊 The Heartstrong Complete Bundle includes both Heartstrong Enzyme Supplement and Heartstrong Vitamin Supplement for comprehensive heart and artery support.
Why Choose Heartstrong Nutraceuticals?
At Heartstrong, we create high-quality supplements based on scientific research. Our products are:
✔️ Made with natural, high-quality ingredients
✔️ Designed to support your body’s natural functions
✔️ Free from unnecessary additives and fillers
Thousands of people trust Heartstrong Nutraceuticals for their cardiovascular wellness.
✨ Read what our customers are saying! Heartstrong Reviews
Take care of your Arterial Health now
Atherosclerosis is a serious condition, but there are natural ways to support cardiovascular health.
✔️ Nattokinase and Serrapeptase can help support circulation and arterial function.
✔️ Vitamin D3 and K2 help ensure calcium is used properly in the body.
✔️ Heartstrong Complete Bundle provides a powerful combination of these essential nutrients.
If you’re looking for a natural way to support your heart and arteries, consider Heartstrong Enzyme Supplement and Heartstrong Vitamin Supplement.
Your heart deserves the best—support it naturally with Heartstrong!